Etymology
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wrinkle (v.)

early 15c. (transitive), probably from stem of Old English gewrinclod "wrinkled, crooked, winding," past participle of gewrinclian "to wind, crease," from perfective prefix ge- + -wrinclian "to wind," from Proto-Germanic *wrankjan, from a nasalized variant of *werg- "to turn," from PIE root *wer- (2) "to turn, bend." Intransitive sense from 1610s. Related: Wrinkled; wrinkling.

wrinkle (n.)

"fold or crease in the extenal body," late 14c.; in cloth or clothing from early 15c., probably from wrinkle (v.). Meaning "defect, problem" first recorded 1640s; that of "idea, device, notion" (especially a new one) is from 1817.

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Definitions of wrinkle
1
wrinkle (v.)
gather or contract into wrinkles or folds; pucker;
Synonyms: purse
wrinkle (v.)
make wrinkles or creases on a smooth surface; make a pressed, folded or wrinkled line in; `crisp' is archaic;
The dress got wrinkled
Synonyms: ruckle / crease / crinkle / scrunch / scrunch up / crisp
wrinkle (v.)
make wrinkled or creased;
Synonyms: furrow / crease
wrinkle (v.)
become wrinkled or crumpled or creased;
This fabric won't wrinkle
Synonyms: rumple / crumple / crease / crinkle
2
wrinkle (n.)
a slight depression or fold in the smoothness of a surface;
ironing gets rid of most wrinkles
Synonyms: furrow / crease / crinkle / seam / line
wrinkle (n.)
a minor difficulty;
they finally have the wrinkles pretty well ironed out
wrinkle (n.)
a clever method of doing something (especially something new and different);
From wordnet.princeton.edu