Old English wid "vast, broad, long," also used of time, from Proto-Germanic *widaz (source also of Old Saxon, Old Frisian wid, Old Norse viðr, Dutch wijd, Old High German wit, German weit), perhaps from PIE *wi-ito-, from root *wi- "apart, away, in half."
Meaning "distended, expanded, spread apart" is from c. 1500; sense of "embracing many subjects" is from 1530s; meaning "missing the intended target" is from 1580s. As a second element in compounds (such as nationwide, worldwide) meaning "extending through the whole of," is is from late Old English. As an adverb, Old English wide. Wide open "unguarded, exposed to attack" (1915) originally was in boxing, etc. Wide awake (adj.) is first recorded 1818; figurative sense of "alert, knowing" is attested from 1833.
word-forming element making verbs (such as darken, weaken) from adjectives or nouns, from Old English -nian, from Proto-Germanic *-inojan (also source of Old Norse -na), from PIE adjectival suffix *-no-. Most active in Middle English and early modern English, hence most verbs in -en are comparatively recent.