Etymology
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vicissitude (n.)

"a passing from one state to another," whether regular or not, 1560s, from French vicissitude (14c.), from Latin vicissitudinem (nominative vicissitudo) "change, interchange, alternation," from vicissim (adv.) "changeably, on the other hand, by turns, in turn," from vicis "a turn, change" (from PIE root *weik- (2) "to bend, to wind"). Related: Vicissitudes.

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Definitions of vicissitude

vicissitude (n.)
a variation in circumstances or fortune at different times in your life or in the development of something;
the project was subject to the usual vicissitudes of exploratory research
vicissitude (n.)
mutability in life or nature (especially successive alternation from one condition to another);
From wordnet.princeton.edu