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variola (n.)

"smallpox," 1771, medical Latin diminutive of Latin varius "changing, various," in this case "speckled, spotted" (see vary).

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Definitions of variola from WordNet

variola (n.)
a highly contagious viral disease characterized by fever and weakness and skin eruption with pustules that form scabs that slough off leaving scars;
Synonyms: smallpox / variola major
From wordnet.princeton.edu