upset (v.)

Old English up, uppe, from Proto-Germanic *upp- "up" (source also of Old Frisian, Old Saxon up "up, upward," Old Norse upp; Danish, Dutch op; Old High German uf, German auf "up"; Gothic iup "up, upward," uf "on, upon, under;" Old High German oba, German ob "over, above, on, upon"), from PIE root *upo "under," also "up from under," hence also "over."

As a preposition, "to a higher place" from c. 1500; also "along, through" (1510s), "toward" (1590s). Often used elliptically for go up, come up, rise up, etc. Up the river "in jail" first recorded 1891, originally in reference to Sing Sing, which is up the Hudson from New York City. To drive someone up the wall (1951) is from the notion of the behavior of lunatics or caged animals. Insulting retort up yours (scil. ass) is attested by late 19c.

Old English settan (transitive) "cause to sit, put in some place, fix firmly; build, found; appoint, assign," from Proto-Germanic *(bi)satejanan "to cause to sit, set" (source also of Old Norse setja, Swedish sätta, Old Saxon settian, Old Frisian setta, Dutch zetten, German setzen, Gothic satjan), causative form of PIE *sod-, a variant of root *sed- (1) "to sit." Also see set (n.2).

The intransitive sense from c. 1200, "be seated." The word was used in many disparate senses by Middle English; sense of "make or cause to do, act, or be; start" and that of "mount a gemstone" attested by mid-13c. Confused with sit since early 14c. Of the sun, moon, etc., "to go down," recorded from c. 1300, perhaps from similar use of the cognates in Scandinavian languages. To set (something) on "incite to attack" (c. 1300) originally was in reference to hounds and game.