Etymology
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uphill (adj.)

1610s, from up + hill (n.). As an adverb from c. 1600. Grose's "Dictionary of the Vulgar Tongue" (1785) has "Uphills, false dice that run high."

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Definitions of uphill
1
uphill (adv.)
against difficulties;
she was talking uphill
uphill (adv.)
upward on a hill or incline;
this street lay uphill
2
uphill (n.)
the upward slope of a hill;
3
uphill (adj.)
sloping upward;
Synonyms: acclivitous / rising
From wordnet.princeton.edu