Etymology
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Words related to up-

up (adv.)

Old English up, uppe, from Proto-Germanic *upp- "up" (source also of Old Frisian, Old Saxon up "up, upward," Old Norse upp; Danish, Dutch op; Old High German uf, German auf "up"; Gothic iup "up, upward," uf "on, upon, under;" Old High German oba, German ob "over, above, on, upon"), from PIE root *upo "under," also "up from under," hence also "over."

As a preposition, "to a higher place" from c. 1500; also "along, through" (1510s), "toward" (1590s). Often used elliptically for go up, come up, rise up, etc. Up the river "in jail" first recorded 1891, originally in reference to Sing Sing, which is up the Hudson from New York City. To drive someone up the wall (1951) is from the notion of the behavior of lunatics or caged animals. Insulting retort up yours (scil. ass) is attested by late 19c.

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up-country (n.)
"interior regions," 1680s, from up- + country (n.). As an adjective from 1810; as an adverb from 1864.
up-current (adj.)
1909, from up- + current (n.).
upland (n.)
"interior district of a country," Old English upland "the country" (as opposed to the town), from up- + land (n.). As an adjective from 14c. Related: Uplandish (Old English uplendisc "rural rustic"); uplander. Jock Upaland was a 16c.-17c. term for a rustic.
uplink (n.)
1968, from up- + link (n.).
up-market (adj.)
1972, from up- + market (n.).
*upo 

Proto-Indo-European root meaning "under," also "up from under," hence "over."

It forms all or part of: above; assume; Aufklarung; eave; eavesdropper; hyphen; hypo-; hypochondria; hypocrisy; hypotenuse; hypothalamus; hypothesis; hypsi-; hypso-; opal; open; oft; often; resuscitate; somber; souffle; source; soutane; souvenir; sub-; subject; sublime; subpoena; substance; subterfuge; subtle; suburb; succeed; succinct; succor; succubus; succumb; sudden; suffer; sufficient; suffix; suffrage; suggestion; summon; supine; supple; supply; support; suppose; surge; suspect; suspend; sustain; up; up-; Upanishad; uproar; valet; varlet; vassal.

It is the hypothetical source of/evidence for its existence is provided by: Sanskrit upa "near, under, up to, on," Greek hypo "under," Latin sub "under, below," Gothic iup, Old Norse, Old English upp "up, upward," Hittite up-zi "rises."

uptight (adj.)
"tense," slang, 1934, from up- + tight (adj.). Meaning "straight-laced" first recorded 1969. It was used in a sense of "excellent" in jazz slang c. 1962.