prefix of reversal, deprivation, or removal (as in unhand, undo, unbutton), Old English on-, un-, from Proto-Germanic *andi- (source also of Old Saxon ant-, Old Norse and-, Dutch ont-, Old High German ant-, German ent-, Gothic and- "against"), from PIE *anti "facing opposite, near, in front of, before, against" (from PIE root *ant- "front, forehead," with derivatives meaning "in front of, before").
More or less confused with un- (1) through similarity in the notions of "negation" and "reversal;" an adjective such as unlocked might represent "not locked" (un- (1)) or the past tense of unlock (un- (2)).
"a load, that which is borne or carried," Old English byrðen "a load, weight, charge, duty;" also "a child;" from Proto-Germanic *burthinjo- "that which is borne" (source also of Old Norse byrðr, Old Saxon burthinnia, German bürde, Gothic baurþei), from PIE root *bher- (1) "to carry," also "to bear children."
The shift from -th- to -d- began early 12c. (compare murder (n.), rudder, afford). Archaic burthen is occasionally retained for the specific sense of "capacity of a ship." Beast of burden is from 1740. Burden of proof (Latin onus probandi) "obligation on one party in an action to establish an alleged fact by proof" is recorded from 1590s.