Old English twa "two," fem. and neuter form of twegen "two" (see twain), from Proto-Germanic *twa (source also of Old Saxon and Old Frisian twene, twa, Old Norse tveir, tvau, Dutch twee, Old High German zwene, zwo, German zwei, Gothic twai), from PIE *duwo, variant of root *dwo- "two."
Two-fisted is from 1774. Two cheers for _____, expressing qualified enthusiasm first recorded 1951 in E.M. Forster's title "Two Cheers for Democracy." Two-dimensional is recorded from 1883; figurative sense of "lacking substance or depth" is attested from 1934.