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transubstantiation (n.)

late 14c., "change of one substance to another," from Medieval Latin trans(s)ubstantiationem (nominative trans(s)ubstantio), noun of action from past participle stem of trans(s)ubstantiare "to change from one substance into another," from Latin trans "across, beyond" (see trans-) + substantiare "to substantiate," from substania "substance" (see substance). Ecclesiastical sense in reference to the Eucharist first recorded 1530s.

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Definitions of transubstantiation from WordNet

transubstantiation (n.)
the Roman Catholic doctrine that the whole substance of the bread and the wine changes into the substance of the body and blood of Christ when consecrated in the Eucharist;
transubstantiation (n.)
an act that changes the form or character or substance of something;
Synonyms: transmutation
From wordnet.princeton.edu