Etymology
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transsexualism (n.)

"intense desire to change one's sexual status, including the anatomical structure," 1953, coined by U.S. physician Harry Benjamin (1885-1986) from trans- + sexual. Transsexuality is recorded from 1941, but was used at first to mean "homosexuality" or "bisexuality." In the current sense from 1955.

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Definitions of transsexualism

transsexualism (n.)
condition in which a person identifies with a gender different from his or her physical gender;
From wordnet.princeton.edu