Etymology
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tranquilizer (n.)

1800, "that which tranquilizes;" from 1824 as "a sedative" (first reference is to ground ivy), agent noun from tranquilize; in reference to one of a large group of anti-anxiety drugs, it is recorded by 1956.

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Definitions of tranquilizer

tranquilizer (n.)
a drug used to reduce stress or tension without reducing mental clarity;
Synonyms: tranquillizer / tranquilliser / antianxiety agent / ataractic drug / ataractic agent / ataractic
From wordnet.princeton.edu