Old English þicce "dense, viscous, solid, stiff; numerous, abundant; deep," also as an adverb, "thickly, closely, often, frequently," from Proto-Germanic *thiku- (source also of Old Saxon thikki, Old High German dicchi, German dick, Old Norse þykkr, Old Frisian thikke), from PIE *tegu- "thick" (source also of Gaelic tiugh). Secondary Old English sense of "close together" is preserved in thickset and proverbial phrase thick as thieves (1833). Meaning "stupid" is first recorded 1590s. Related: Thickly.
As a noun, "the thick part" (of anything), from mid-13c. Phrase through thick and thin, indicating rough or smooth going, hence "unwaveringly," is in Chaucer (late 14c.); thick-skinned is attested from 1540s; in figurative sense from c. 1600. To be in the thick of some action, etc., "to be at the most intense moment" is from 1680s, from a Middle English noun sense.
word-forming element making verbs (such as darken, weaken) from adjectives or nouns, from Old English -nian, from Proto-Germanic *-inojan (also source of Old Norse -na), from PIE adjectival suffix *-no-. Most active in Middle English and early modern English, hence most verbs in -en are comparatively recent.