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space (n.)

c. 1300, "extent or area; room" (to do something), a shortening of Old French espace "period of time, distance, interval" (12c.), from Latin spatium "room, area, distance, stretch of time," a word of unknown origin (also source of Spanish espacio, Italian spazio).

From early 14c. as "a place," also "amount or extent of time." From mid-14c. as "distance, interval of space;" from late 14c. as "ground, land, territory; extension in three dimensions; distance between two or more points." From early 15c. as "size, bulk," also "an assigned position." Typographical sense is attested from 1670s (typewriter space-bar is from 1876, earlier space-key, 1860).

Astronomical sense of "stellar depths, immense emptiness between the worlds" is by 1723, perhaps as early as "Paradise Lost" (1667), common from 1890s. Space age is attested from 1946. Many compounds first appeared in science fiction and speculative writing, such as spaceship (1894, "A Journey in Other Worlds," John Jacob Astor); spacecraft (1928, "Popular Science"); space travel (1931); space station (1936, "Rockets Through Space"); spaceman (1942, "Thrilling Wonder Stories"). Space race attested from 1959. Space shuttle attested by 1970.

Space isn't remote at all. It's only an hour's drive away if your car could go straight upwards. [Sir Fred Hoyle, "London Observer," 1979]

space (v.)

1540s, "to make of a certain extent;" 1680s in typography; 1703 as "to arrange at set intervals," from space (n.). Meaning "to be in a state of drug-induced euphoria" is recorded from 1968. Space cadet "eccentric person disconnected with reality" (often implying an intimacy with hallucinogenic drugs) is a 1960s phrase, probably traceable to 1950s U.S. sci-fi television program "Tom Corbett, Space Cadet," which was watched by many children who dreamed of growing up to be one and succeeded. Related: Spaced; spacing.

space (adj.)

c. 1600, from space (n.). Meaning "having to do with outer space" is from 1894.

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Definitions of space from WordNet
1
space (n.)
the unlimited expanse in which everything is located;
they tested his ability to locate objects in space
Synonyms: infinite
space (n.)
an empty area (usually bounded in some way between things);
the architect left space in front of the building
they stopped at an open space in the jungle
the space between his teeth
space (n.)
an area reserved for some particular purpose;
the laboratory's floor space
space (n.)
any location outside the Earth's atmosphere;
the astronauts walked in outer space without a tether
the first major milestone in space exploration was in 1957, when the USSR's Sputnik 1 orbited the Earth
Synonyms: outer space
space (n.)
a blank character used to separate successive words in writing or printing;
he said the space is the most important character in the alphabet
Synonyms: blank
space (n.)
the interval between two times;
it all happened in the space of 10 minutes
Synonyms: distance
space (n.)
a blank area;
write your name in the space provided
Synonyms: blank space / place
space (n.)
one of the areas between or below or above the lines of a musical staff;
the spaces are the notes F-A-C-E
space (n.)
(printing) a block of type without a raised letter; used for spacing between words or sentences;
Synonyms: quad
2
space (v.)
place at intervals;
From wordnet.princeton.edu