Etymology
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southpaw (n.)

"lefthander," 1885, originally baseball slang, of pitchers, often said to have been coined by Finley Peter Dunne ("Mr. Dooley"), Chicago sports journalist and humorist, in the days when, it is said, baseball diamonds regularly were laid out with home plate to the west. But south paw "a person's left hand" is attested from 1848 in the slang of pugilism.

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Definitions of southpaw

southpaw (n.)
a baseball pitcher who throws the ball with the left hand;
Synonyms: left-handed pitcher / left-hander / left hander / lefthander / lefty
southpaw (n.)
a person who uses the left hand with greater skill than the right;
their pitcher was a southpaw
Synonyms: left-hander / lefty
From wordnet.princeton.edu