sourpuss (n.)

Old English sur "sour, tart, acid, fermented," from Proto-Germanic *sura- "sour" (source also of Old Norse surr, Middle Dutch suur, Dutch zuur, Old High German sur, German sauer), from PIE root *suro- "sour, salty, bitter" (source also of Old Church Slavonic syru, Russian syroi "moist, raw;" Lithuanian sūras "salty," sūris "cheese").

Meaning "having a peevish disposition" is from early 13c. Sense in whisky sour (1885) is "with lemon added" (1862). Sour cream is attested from 1855. French sur "sour, tart" (12c.) is a Germanic loan-word.

"the face" (but sometimes, especially in pugilism slang, "the mouth"), especially when sour-looking or ugly, 1890, slang, from Irish pus "lip, mouth."