Words related to small
small beer (n.) 1560s, originally "weak beer;" used figuratively of small things or trifling matters. Small with the meaning "of low alcoholic content" is attested from mid-15c.
smallpox (n.) acute, highly contagious disease, 1510s, small pokkes, as distinguished from great pox "syphilis;" from small-pock "pustule caused by smallpox" (mid-15c.); see small (adj.) + pox. Compare French petite vérole. Fatal in a quarter to a third of unvaccinated cases.