1630s, squunck, from a southern New England Algonquian language (perhaps Massachusett) word, from Proto-Algonquian */šeka:kwa/, from */šek-/ "to urinate" + */-a:kw/ "fox." As an insult, attested from 1841. Skunk cabbage, which grows in moist ground in the U.S. and gives of a strong pungent odor when bruised, is attested from 1751; earlier was skunkweed (1738).
"to completely defeat (in a game), to shut out from scoring," 1831, from skunk (n.). Related: Skunked; skunking.