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sissy (n.)

1768, "sister," colloquial extended form of sis (q.v.). Meaning "effeminate man" is recorded by 1873; the adjective in this sense is from 1891. Also in 19c. sometimes a women's or girl's name, short for Cecilia, Priscilla, etc.). Related: Sissiness. Sissy bar is recorded from 1969.

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Definitions of sissy from WordNet
1
sissy (n.)
a timid man or boy considered childish or unassertive;
Synonyms: pantywaist / pansy / milksop / Milquetoast
2
sissy (adj.)
having unsuitable feminine qualities;
Synonyms: effeminate / emasculate / epicene / cissy / sissified / sissyish
From wordnet.princeton.edu