sine prole

c. 1300, sauns, saun, "without" (mid-12c. in surnames), from Old French san, sans, sen, senz (some of the forms with adverbial genitive -s) "without, except, apart, not counting." This is cognate with Provençal senes, Old Catalan senes, Old Spanish sen (Spanish sin), Old Italian sen, all from Vulgar Latin *sene, from Latin sine "without," an enlarged form of sed, se "without" (from PIE root *sen(e)- "apart, separated;" see sunder).

"A French word which has existed long in English without becoming naturalized; now archaic or affected, except as used in heraldry ..." [Century Dictionary, 1891]; OED writes that the words limited modern use is "chiefly with reminiscence of Shakespere," which it spells that way. In reference to fonts, by 1927, short for sans-serif. Sans souci, French, as an adverbial phrase "free from care, without care or concern," was the name of Frederick the Great's royal palace at Potsdam. 

1640s, "producing young or fruit;" 1650s, "producing offspring or fruit in abundance;" from French prolifique (16c.), from Medieval Latin prolificus, from Latin proles "offspring" + combining form of facere "to make, to do" (from PIE root *dhe- "to set, put"). Latin proles is contracted from *pro-oles, from PIE *pro-al-, from *pro- "forth" (see pro-) + root *al- (2) "to grow, nourish." Related: Prolifical (c. 1600).

Prolific is in common use, but to make a satisfactory noun from it has passed the wit of man. [Fowler]

Gower (1393) has prolificacioun, from Medieval Latin prolificationem; prolificacy (1796) and prolificness (1690s) also have been tried.