Etymology
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significant (adj.)

1570s, "having a meaning," from Latin significantem (nominative significans, present participle of significare "make known, indicate" (see signify). Earlier in the same sense was significative (c. 1400). Often "having a special or secret meaning," hence "important" (1761). Related: Significantly. Significant figure is from 1680s. Significant other (n.) attested by 1961, in psychology, "the most influential other person in the patient's world."

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Definitions of significant

significant (adj.)
rich in significance or implication;
a significant silence
Synonyms: meaning / pregnant
significant (adj.)
important in effect or meaning;
a significant contribution
statistically significant
a significant change in tax laws
a significant change in the Constitution
significant details
Synonyms: important
significant (adj.)
of considerable importance, size, or worth;
Synonyms: substantial
significant (adj.)
too closely correlated to be attributed to chance and therefore indicating a systematic relation;
no significant difference was found
the interaction effect is significant at the .01 level
From wordnet.princeton.edu