c. 1300, "to make the sign of the cross," from Old French signier "to make a sign (to someone); to mark," from Latin signare "to set a mark upon, mark out, designate; mark with a stamp; distinguish, adorn;" figuratively "to point out, signify, indicate," from signum "identifying mark, sign" (see sign (n.)). Sense of "to mark, stamp" is attested from mid-14c.; that of "to affix one's name" is from late 15c. Meaning "to communicate by hand signs" is recorded from 1700. Related: Signed; signing.
Old English up, uppe, from Proto-Germanic *upp- "up" (source also of Old Frisian, Old Saxon up "up, upward," Old Norse upp; Danish, Dutch op; Old High German uf, German auf "up"; Gothic iup "up, upward," uf "on, upon, under;" Old High German oba, German ob "over, above, on, upon"), from PIE root *upo "under," also "up from under," hence also "over."
As a preposition, "to a higher place" from c. 1500; also "along, through" (1510s), "toward" (1590s). Often used elliptically for go up, come up, rise up, etc. Up the river "in jail" first recorded 1891, originally in reference to Sing Sing, which is up the Hudson from New York City. To drive someone up the wall (1951) is from the notion of the behavior of lunatics or caged animals. Insulting retort up yours (scil. ass) is attested by late 19c.