Etymology
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setback (n.)

also set-back, 1670s, "reversal, check to progress," from set (v.) + back (adv.). Sometimes backset (1721) was used in the same sense. Meaning "space between a building and a property line" is from 1916. To set (someone) back "cost" is from 1900.

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Definitions of setback

setback (n.)
an unfortunate happening that hinders or impedes; something that is thwarting or frustrating;
Synonyms: reverse / reversal / blow / black eye
From wordnet.princeton.edu

Dictionary entries near setback

set

Set

set off

seta

set-aside

setback

Seth

setness

sett

settee

setter