"disposition to withdraw from some combination or union," 1620s, from separate + -ism. Especially in reference to a withdrawal from an established church, or to Church and State; from 1866 in a purely political sense.
early 15c., separaten, transitive, "remove, detach completely; divide (something), sever the connection or association of," from Latin separatus, past participle of separare "to pull apart," from se- "apart" (see secret (n.)) + parare "make ready, prepare" (from PIE root *pere- (1) "to produce, procure"). Sever (q.v.) is a doublet, via French. Intransitive sense of "to part, be or become disunited or disconnected" is by 1630s of things, 1680s of persons. Related: Separated; separating.
word-forming element making nouns implying a practice, system, doctrine, etc., from French -isme or directly from Latin -isma, -ismus (source also of Italian, Spanish -ismo, Dutch, German -ismus), from Greek -ismos, noun ending signifying the practice or teaching of a thing, from the stem of verbs in -izein, a verb-forming element denoting the doing of the noun or adjective to which it is attached. For distinction of use, see -ity. The related Greek suffix -isma(t)- affects some forms.
<a href="https://www.etymonline.com/word/separatism">Etymology of separatism by etymonline</a>
Harper, D. (n.d.). Etymology of separatism. Online Etymology Dictionary. Retrieved $(datetime), from https://www.etymonline.com/word/separatism