self-interest (n.)

word forming element indicating "oneself," also "automatic," from Old English use of self (pron.) in compounds, such as selfbana "suicide," selflice "self-love, pride, vanity, egotism," selfwill "free will." Middle English had self-witte "one's own knowledge and intelligence" (early 15c.).

OED counts 13 such compounds in Old English. Middle English Compendium lists four, counting the self-will group as a whole. It re-emerges as a living word-forming element mid-16c., "probably to a great extent by imitation or reminiscence of Greek compounds in (auto-)," and formed a great many words in the pamphlet disputes of the 17c.

mid-15c., "legal claim or right; a concern; a benefit, advantage, a being concerned or affected (advantageously)," from Old French interest "damage, loss, harm" (Modern French intérêt), from noun use of Latin interest "it is of importance, it makes a difference," third person singular present of interresse "to concern, make a difference, be of importance," literally "to be between," from inter "between" (see inter-) + esse "to be" (from PIE root *es- "to be"). The sense development to "profit, advantage" in French and English is not entirely clear.

The earlier Middle English word was interesse (late 14c.), from Anglo-French interesse "what one has a legal concern in," from Medieval Latin interesse "compensation for loss," noun use of Latin interresse (compare German Interesse, from the same Medieval Latin source).

Financial sense of "money paid for the use of money lent" (1520s) earlier was distinguished from usury (illegal under Church law) by being in reference to "compensation due from a defaulting debtor." Sense of "personal or selfish consideration" is from 1620s. Meaning "business in which several people are interested" is from 1670s. Meaning "curiosity, feeling that something concerns one, appreciative or sympathetic regard" is first attested 1771. Interest group is attested from 1907; interest rate by 1868.