Etymology
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sclerosis (n.)

"a hardening," especially "morbid hardening of the tissue," late 14c., from Medieval Latin sclerosis "a hardness, hard tumor," from Greek sklērosis "hardening," from sklēros "hard" (see sclero-). Figurative use, "excessive resistance to change," is by 1954.

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Definitions of sclerosis

sclerosis (n.)
any pathological hardening or thickening of tissue;
Synonyms: induration
From wordnet.princeton.edu