1866, from Modern Latin, from Greek skleros "hard" (see sclerosis) + derma "skin" (from PIE root *der- "to split, flay, peel," with derivatives referring to skin and leather). Related: Sclerodermatous; sclerodermatic.
It is the hypothetical source of/evidence for its existence is provided by: Sanskrit drnati "cleaves, bursts;" Greek derein "to flay;" Armenian terem "I flay;" Old Church Slavonic dera "to burst asunder;" Breton darn "piece;" Old English teran "to tear, lacerate."
Others are reading
Definitions of scleroderma from WordNet
an autoimmune disease that affects the blood vessels and connective tissue; fibrous connective tissue is deposited in the skin;
genus of poisonous fungi having hard-skinned fruiting bodies: false truffles;