"blood-red," late 14c. (late 12c. as a surname), from Old French sanguin (fem. sanguine), from Latin sanguineus "of blood," also "bloody, bloodthirsty," from sanguis (genitive sanguinis) "blood" (see sanguinary). Meaning "cheerful, hopeful, confident" first attested c. 1500, because these qualities were thought in old medicine to spring from an excess of blood as one of the four humors. Also in Middle English as a noun, "type of red cloth" (early 14c.).