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safe (adj.)

c. 1300, "unscathed, unhurt, uninjured; free from danger or molestation, in safety, secure; saved spiritually, redeemed, not damned;" from Old French sauf "protected, watched-over; assured of salvation," from Latin salvus "uninjured, in good health, safe," related to salus "good health," saluber "healthful," all from PIE *solwos from root *sol- "whole, well-kept."

As a quasi-preposition from c. 1300, on model of French and Latin cognates. From late 14c. as "rescued, delivered; protected; left alive, unkilled." Meaning "not exposed to danger" (of places) is attested from late 14c.; of actions, etc., "free from risk," first recorded 1580s. Meaning "sure, reliable, not a danger" is from c. 1600. Sense of "conservative, cautious" is from 1823. Paired alliteratively with sound (adj.) from late 14c. The noun safe-conduct (late 13c.) is from Old French sauf-conduit (13c.).

safe (n.)

"chest for keeping food or valuables," early 15c., save, from French en sauf "in safety," from sauf (see safe (adj.)). Spelling with -f- first recorded 1680s, from influence of safe (adj.).

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Definitions of safe from WordNet
1
safe (adj.)
having reached a base without being put out;
the runner was called safe when the baseman dropped the ball
safe (adj.)
free from danger or the risk of harm;
you will be safe here
a safe bet
a safe place
a safe trip
safe (adj.)
(of an undertaking) secure from risk;
safe (adj.)
financially safe;
Synonyms: dependable / good / secure
2
safe (n.)
strongbox where valuables can be safely kept;
safe (n.)
a ventilated or refrigerated cupboard for securing provisions from pests;
safe (n.)
contraceptive device consisting of a sheath of thin rubber or latex that is worn over the penis during intercourse;
Synonyms: condom / rubber / safety / prophylactic
From wordnet.princeton.edu