roadhouse (n.)

Middle English rode, from Old English rad "riding expedition, journey, hostile incursion," from Proto-Germanic *raido (source also of Old Frisian red "ride," Old Saxon reda, Middle Dutch rede, Old High German reita "foray, raid"), from PIE *reidh- "to ride" (see ride (v.)). Also related to raid (n.).

In Middle English it was still, "a riding, a journey on horseback; a mounted raid;" the sense of "an open passage or way for traveling between two places" is recorded from 1590s, and the older senses now are obsolete. "The late appearance of this sense makes its development from sense 1 somewhat obscure," according to OED, which however finds similar evolutions in Flemish and Frisian words. The modern spelling was established 18c.  

The meaning "narrow stretch of sheltered water near shore where ships can lie at anchor" is from early 14c. (as in Virginia's Hampton Roads). In late 19c. U.S. use it is often short for railroad.

On the road "traveling" is from 1640s. Road test (n.) of a vehicle's performance is by 1906; as a verb from 1937. Road hog "one who is objectionable on the road" [OED] is attested from 1886; road rage is by 1988. Road map is from 1786; road trip is by 1950, originally of baseball teams. Old English had radwerig "weary of traveling."

Old English hus "dwelling, shelter, building designed to be used as a residence," from Proto-Germanic *hūsan (source also of Old Norse, Old Frisian hus, Dutch huis, German Haus), of unknown origin, perhaps connected to the root of hide (v.) [OED]. In Gothic only in gudhus "temple," literally "god-house;" the usual word for "house" in Gothic being according to OED razn.

Meaning "family, including ancestors and descendants, especially if noble" is from c. 1000. Zodiac sense is first attested late 14c. The legislative sense (1540s) is transferred from the building in which the body meets. Meaning "audience in a theater" is from 1660s (transferred from the theater itself, playhouse). Meaning "place of business" is 1580s. The specialized college and university sense (1530s) also applies to both buildings and students collectively, a double sense found earlier in reference to religious orders (late 14c.). As a dance club DJ music style, probably from the Warehouse, a Chicago nightclub where the style is said to have originated.

To play house is from 1871; as suggestive of "have sex, shack up," 1968. House arrest first attested 1936. House-painter is from 1680s. House-raising (n.) is from 1704. On the house "free" is from 1889. House and home have been alliteratively paired since c. 1200.

And the Prophet Isaiah the sonne of Amos came to him, and saide vnto him, Thus saith the Lord, Set thine house in order: for thou shalt die, and not liue. [II Kings xx.1, version of 1611]