Etymology
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resistance (n.)

mid-14c., resistence, "moral or political opposition;" late 14c., "military or armed physical opposition by force; difficulty, trouble," from Old French resistance, earlier resistence, and directly from Medieval Latin resistentia, from present-participle stem of Latin resistere "make a stand against, oppose" (see resist).

From 1580s as "power or capacity of resisting." The meaning "organized covert opposition to an occupying or ruling power" [OED] is from 1939. The electromagnetic sense of "non-conductivity" is from 1760. Also used  in science and engineering with a sense of "force exerted by a medium to retard motion through it," hence the figurative phrase path of least resistance "easiest method or course" (1825), earlier a term in physical sciences and engineering.

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Definitions of resistance

resistance (n.)
the action of opposing something that you disapprove or disagree with;
he encountered a general feeling of resistance from many citizens
Synonyms: opposition
resistance (n.)
any mechanical force that tends to retard or oppose motion;
resistance (n.)
a material's opposition to the flow of electric current; measured in ohms;
Synonyms: electric resistance / electrical resistance / impedance / resistivity / ohmic resistance
resistance (n.)
the military action of resisting the enemy's advance;
the enemy offered little resistance
resistance (n.)
(medicine) the condition in which an organism can resist disease;
Synonyms: immunity
resistance (n.)
the capacity of an organism to defend itself against harmful environmental agents;
these trees are widely planted because of their resistance to salt and smog
resistance (n.)
a secret group organized to overthrow a government or occupation force;
Synonyms: underground
resistance (n.)
the degree of unresponsiveness of a disease-causing microorganism to antibiotics or other drugs (as in penicillin-resistant bacteria);
resistance (n.)
(psychiatry) an unwillingness to bring repressed feelings into conscious awareness;
resistance (n.)
an electrical device that resists the flow of electrical current;
Synonyms: resistor
resistance (n.)
group action in opposition to those in power;
From wordnet.princeton.edu