Etymology
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regardless (adj.)

1590s, "indifferent, not heeding or looking," from regard (n.) + -less. As elliptical for "regardless of consequences, expenses, etc.," from 1872. Regardful is attested from 1580s. Related: Regardlessly; regardlessness.

updated on June 15, 2021

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Definitions of regardless from WordNet
1
regardless (adv.)
in spite of everything; without regard to drawbacks;
he carried on regardless of the difficulties
Synonyms: irrespective / disregardless / no matter / disregarding
2
regardless (adj.)
(usually followed by `of') without due thought or consideration;
crushing the blooms with regardless tread
Synonyms: careless
Etymologies are not definitions. From wordnet.princeton.edu, not affiliated with etymonline.