"smart, sarcastic remark," 1530s, a variant of quippy in the same sense (1510s), perhaps from Latin quippe "indeed, of course, as you see, naturally, obviously" (used sarcastically), from quid "what" (neuter of pronoun quis "who," from PIE root *kwo-, stem of relative and interrogative pronouns) + emphatic particle -pe. Compare quibble (n.).
1570s, "use quips; assail with clever, sarcastic remarks," from quip (n.). The sense of "to say or reply as a quip" is by 1950. Related: Quipped; quipping.