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queer (adj.)

c. 1500, "strange, peculiar, odd, eccentric," from Scottish, perhaps from Low German (Brunswick dialect) queer "oblique, off-center," which is related to German quer "oblique, perverse, odd," from Old High German twerh "oblique" (from PIE root *terkw- "to twist"). For the suggested sense evolution, compare cross (adj.). But OED is against this etymology on grounds of timing and sense.

The meaning "appearing, feeling, or behaving otherwise than is usual or normal" is by 1781. The colloquial sense of "open to suspicion, doubtful as to honesty" is by 1740. As a slang noun, "counterfeit money," by 1812; to shove the queer (1859) was "to pass counterfeit money. Queer Street (1811) was the imaginary place where persons in difficulties and shady characters lived, hence, in cant generally, "contrary to one's wishes."

Sense of "homosexual" is attested by 1922; the noun in this sense is 1935, from the adjective. Related: Queerly. Queer studies as an academic discipline is attested from 1994.

Among the entries in the 1811 "Lexicon Balatronicum" are: Queer as Dick's Hatband "Out of order without knowing one's disease"; Queer Bitch "An odd out of the way fellow"; Queer Ken "A prison";  Queer Mort "A diseased strumpet";  Queer Rooster "An informer that pretends to be sleeping and thereby overhears the conversation of thieves in nightcellars."

queer (v.)

"to spoil, ruin," 1812, slang, from queer (adj.). Related: Queered; queering. Earlier it meant "to puzzle, ridicule, deride, cheat" (1790). To queer the pitch (1846) is in reference to the patter of an itinerant tradesman or showman (see pitch (n.1)).

These wanderers, and those who are still seen occasionally in the back streets of the metropolis, are said to 'go a-pitching ;' the spot they select for their performance is their 'pitch,' and any interruption of their feats, such as an accident, or the interference of a policeman, is said to 'queer the pitch,'—in other words, to spoil it. [Thomas Frost, "Circus Life and Circus Celebrities," London, 1875]

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Definitions of queer from WordNet
1
queer (v.)
hinder or prevent (the efforts, plans, or desires) of;
Synonyms: thwart / spoil / scotch / foil / cross / frustrate / baffle / bilk
queer (v.)
put in a dangerous, disadvantageous, or difficult position;
Synonyms: expose / scupper / endanger / peril
2
queer (adj.)
homosexual or arousing homosexual desires;
Synonyms: gay / homophile
queer (adj.)
beyond or deviating from the usual or expected;
something definitely queer about this town
Synonyms: curious / funny / odd / peculiar / rum / rummy / singular
3
queer (n.)
offensive term for a homosexual man;
Synonyms: fagot / faggot / fag / fairy / nance / pansy / queen / poof / poove / pouf
From wordnet.princeton.edu