Etymology
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quarto (n.)

"book from paper folded twice to make four pages to the sheet, size of book in which the leaf is one-fourth of a certain size of paper," late 15c., in the phrase in quarto, from Medieval Latin in quarto "in the fourth (part of a sheet of paper)," from quarto, ablative singular of Latin quartus "the fourth, fourth part" (related to quattuor "four," from PIE root *kwetwer- "four").

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Definitions of quarto

quarto (n.)
the size of a book whose pages are made by folding a sheet of paper twice to form four leaves;
Synonyms: "to
From wordnet.princeton.edu