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profanation (n.)

"act of violating sacred things or treating them with contempt or irreverence," 1550s, from French profanation (Old French prophanation, 15c.) or directly from Late Latin profanationem (nominative profanatio), noun of action from past-participle stem of profanare "render unholy, deprive of sanctity" (see profane (adj.)).

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Definitions of profanation from WordNet

profanation (n.)
blasphemous behavior; the act of depriving something of its sacred character;
profanation (n.)
degradation of something worthy of respect; cheapening;
From wordnet.princeton.edu