c. 1400, "the foreskin," also "the state of being uncircumcised," from Old French prepuce, from Latin praeputium "foreskin," possibly from prae "before" (see pre-) + *putos "penis." Earlier in English as prepucy (late 14c.), directly from Latin. Related: Preputial.
And in this temple was Charlemayn whan þat the aungell broughte him the prepuce of oure lord Ihesu crist of his Circumcisioun. And after kyng Charles leet bryngen it to Parys in to his chapell And after þat he leet brynge it to Peyteres & after þat to Chartres. [Sir John Mandeville, "Voiage and Travaile," mid-14c.]