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pox (n.)

"disease characterized by eruptive sores," late 15c., spelling alteration of pockes (late 13c. in this sense), plural of pocke "pustule" (see pock (n.)). Especially (after c. 1500) of syphilis.

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Definitions of pox

pox (n.)
a common venereal disease caused by the treponema pallidum spirochete; symptoms change through progressive stages; can be congenital (transmitted through the placenta);
Synonyms: syphilis / syph / lues venerea / lues
pox (n.)
a contagious disease characterized by purulent skin eruptions that may leave pock marks;
From wordnet.princeton.edu