Etymology
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poisonous (adj.)

"having the properties of a poison; containing poison," 1570s, from poison (n.) + -ous. Failed rivals were poisonsome (1590s), poisonful (1550s), poisony (1590s). Earlier poisoned was used (late 15c.). Related: Poisonously; poisonousness. Compare venomous.

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Definitions of poisonous

poisonous (adj.)
having the qualities or effects of a poison;
Synonyms: toxicant
poisonous (adj.)
not safe to eat;
poisonous (adj.)
marked by deep ill will; deliberately harmful;
poisonous hate
Synonyms: venomous / vicious
From wordnet.princeton.edu