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poignance (n.)

1769, of words, expressions, etc., "point, sharpness, power of irritation;" see poignant + -ance. As "power of stimulating the organs of taste" by 1782; in reference to emotional states, "painfulness, bitterness" by 1812.

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Definitions of poignance from WordNet

poignance (n.)
a state of deeply felt distress or sorrow;
Synonyms: poignancy
From wordnet.princeton.edu