Etymology
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Words related to pleio-

*pele- (1)
*pelə-, Proto-Indo-European root meaning "to fill," with derivatives referring to abundance and multitude.

It forms all or part of: accomplish; complete; compliment; comply; depletion; expletive; fele; fill; folk; full (adj.); gefilte fish; hoi polloi; implement; manipulation; nonplus; plebe; plebeian; plebiscite; pleiotropy; Pleistocene; plenary; plenitude; plenty; plenum; plenipotentiary; pleo-; pleonasm; plethora; Pliocene; pluperfect; plural; pluri-; plus; Pollux; poly-; polyamorous; polyandrous; polyclinic; polydactyl; polydipsia; Polydorus; polyethylene; polyglot; polygon; polygraph; polygyny; polyhedron; polyhistor; polymath; polymer; polymorphous; Polynesia; polyp; Polyphemus; polyphony; polysemy; polysyllabic; polytheism; replenish; replete; supply; surplus; volkslied.

It is the hypothetical source of/evidence for its existence is provided by: Sanskrit purvi "much," prayah "mostly;" Avestan perena-, Old Persian paru "much;" Greek polys "much, many," plethos "people, multitude, great number," ploutos "wealth;" Latin plus "more," plenus "full;" Lithuanian pilus "full, abundant;" Old Church Slavonic plunu; Gothic filu "much," Old Norse fjöl-, Old English fela, feola "much, many;" Old English folgian; Old Irish lan, Welsh llawn "full;" Old Irish il, Welsh elu "much."
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pleiotropy (n.)

"production by a single gene of two or more apparently unrelated effects," 1921, from German pleiotrop (1910), from Greek pleiōn "greater in quantity, the more part, very many" (see pleio-) + trope "a turn, turning" (from PIE root *trep- "to turn"). Related: Pleiotropic; pleiotropism.

Pleistocene (adj.)

a name given by geologists to the lower division of the Quaternary, now reckoned as from about 2.6 million years ago and essentially "pertaining to the glacial period," 1839, coined by Lyell from Greek pleistos "most" (superlative of polys "much;" see pleio-) + -cene "recent."

pleistodox (adj.)

"holding the opinion of the majority," 1814 (Coleridge), from Greek pleistos "most," from pleiōn "the more part, very man" (see pleio-) + doxa "opinion, praise" (from dokein "to seem," from PIE root *dek- "to take, accept").

plio- 
word-forming element, Latinate form of pleio-.
Pliocene (adj.)

in geology, in reference to the most recent division of the Tertiary, 1833, from plio- "more" (Latinized form of pleio-) + -cene "recent." Execrated by classical purists (along with Miocene and Eocene); a proper form from Greek would be *Plionocene. Roughly 5.3 million to 2.6 million years ago, it is distinguished from the other two epochs by having more fossils of still-existing species. The Pliocene and the more recent Pleistocene, both comparatively brief, commonly now are combined as the Plio-Pleistocene