1797, "seed of an apple (or orange)," a shortened form of pipin "seed of a fleshy fruit" (early 14c.), from Old French pepin (13c.), probably from a root *pipp-, expressing smallness (compare Italian pippolo, Spanish pepita "seed, kernel").
"disease of poultry consisting of a secretion of thick mucus which forms a white scale around the tongue," late 14c., pippe, probably from Middle Dutch pippe "mucus," from West Germanic *pipit (source also of East Frisian pip, Middle High German pfipfiz, German Pips), an early borrowing from Vulgar Latin *pippita, an unexplained alteration of Latin pituita "phlegm" (see pituitary).
"one of the spots on a playing card, dice, etc.," c. 1600, peep, of unknown origin. Because of the original form and difference of dates, it is now not considered to be from pip (n.1). Related: Pips.