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pill (n.)

c. 1400, pille, "globular or ovoid mass of medicinal substance of a size convenient for swallowing," from Middle Dutch or Middle Low German pille and Old French pile, all from Latin pilula "pill," literally "little ball," diminutive of pila "a ball, playing ball," which is perhaps related to pilus "hair" if the original notion was "hairball."

The figurative sense "something disagreeable that must be accepted ('swallowed')" is from 1540s. The slang meaning "disagreeable or objectionable person, bore," is by 1871. The pill "contraceptive pill" is from 1957.

pill (v.1)

1736, "to dose on pills," from pill (n.). From 1882 as "to form into pills." In club slang, "to reject by vote, blackball" (1855). Related: Pilled; pilling.

pill (v.2)

"deprive of hair, make bald," c. 1400, from late Old English, from Old French piller, from Latin pilare "to peel strip, deprive of hair," from pilus "hair" (see pile (n.3)). Now displaced by peel.

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Definitions of pill

pill (n.)
something that resembles a tablet of medicine in shape or size;
pill (n.)
a dose of medicine in the form of a small pellet;
Synonyms: lozenge / tablet / tab
pill (n.)
a unpleasant or tiresome person;
pill (n.)
something unpleasant or offensive that must be tolerated or endured;
his competitor's success was a bitter pill to take
pill (n.)
a contraceptive in the form of a pill containing estrogen and progestin to inhibit ovulation and so prevent conception;
Synonyms: birth control pill / contraceptive pill / oral contraceptive pill / oral contraceptive / anovulatory drug / anovulant
From wordnet.princeton.edu