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pest (n.)

1550s (in imprecations, "a pest upon ____," etc.), "plague, pestilence, epidemic disease," from French peste (1530s), from Latin pestis "deadly contagious disease; a curse, bane," a word of uncertain origin. Meaning "any noxious, destructive, or troublesome person or thing" is attested by c. 1600. Pest-house "hospital for persons suffering from infectious diseases" is from 1610s.

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Definitions of pest from WordNet

pest (n.)
a serious (sometimes fatal) infection of rodents caused by Yersinia pestis and accidentally transmitted to humans by the bite of a flea that has bitten an infected animal;
Synonyms: plague / pestilence / pestis
pest (n.)
any epidemic disease with a high death rate;
Synonyms: plague / pestilence
pest (n.)
a persistently annoying person;
Synonyms: blighter / cuss / pesterer / gadfly
pest (n.)
any unwanted and destructive insect or other animal that attacks food or crops or livestock etc.;
he sprayed the garden to get rid of pests
many pests have developed resistance to the common pesticides
From wordnet.princeton.edu