Etymology
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moxie (n.)

"courage," 1930, from Moxie, brand name of a bitter, non-alcoholic drink, 1885, perhaps as far back as 1876 as the name of a patent medicine advertised to "build up your nerve." Despite legendary origin stories put out by the company that made it, it is perhaps ultimately from a New England Indian word (it figures in river and lake names in Maine, where it is apparently from Abenaki and means "dark water"). Much-imitated in its day; in 1917 the Moxie Company won an infringement suit against a competitor's beverage marketed as "Proxie."

updated on March 12, 2019

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Definitions of moxie from WordNet

moxie (n.)
fortitude and determination;
Synonyms: backbone / grit / guts / sand / gumption
Etymologies are not definitions. From wordnet.princeton.edu, not affiliated with etymonline.