Etymology
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mono

1959 as a shortening of monophonic in reference to recordings; earlier used among printers for "monotype machine" (c. 1925) and generally for monochrome (motorcar, etc.), 1940s. From 1964 as short for mononucleosis.

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Definitions of mono
1
mono (n.)
an acute disease characterized by fever and swollen lymph nodes and an abnormal increase of mononuclear leucocytes or monocytes in the bloodstream; not highly contagious; some believe it can be transmitted by kissing;
Synonyms: infectious mononucleosis / mononucleosis / glandular fever / kissing disease
2
mono (adj.)
designating sound transmission or recording or reproduction over a single channel;
Synonyms: monophonic / single-channel
From wordnet.princeton.edu