Etymology
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Words related to molecule

mole (n.3)

"massive structure used as a breakwater," 1540s, from French môle "breakwater" (16c.), ultimately from Latin moles "mass, massive structure, barrier," perhaps from PIE root *mō- "to exert oneself" (source also of Greek molos "effort," molis "hardly, scarcely;" German mühen "to tire," müde "weary, tired;" Russian majat' "to fatigue, exhaust," maja "hard work").

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-cule 
word-forming element used to make diminutives, from French -cule or directly from Latin -culus (masc.), -cula (fem.), -culum (neuter); these appear to be variants of the diminutive suffix -ulus (see -ule) used after -i-, -e-, -u-, and consonant stems [Gildersleeve], or might be a double-diminutive involving "an ancient diminutive suffix *-qo-" [Palmer, "The Latin Language"].

There also was a Latin instrumentive suffix -culo-, -culum in baculum "walking stick," gubernaculum "rudder, helm; management, government," operculum "cover, lid," obstaculum "a hindrance, obstacle," oraculum "divine announcement."
macromolecule (n.)

1886, "molecule consisting of several molecules," a sense now obsolete, from macro- + molecule. Apparently coined in "On Macro-molecules, with the Determinations of the Form of Some of Them," by Anglo-Irish physicist G. Johnstone Stoney (1826–1911). Originally of crystals. Meaning "molecule composed of many atoms" is by 1935, from German makromolekul (1922). Related: Macromolecular (by 1931).

mole (n.4)

unit of molecular quantity, 1902, from German Mol coined 1900 by German chemist Wilhelm Ostwald, short for Molekül (see molecule).

molecular (adj.)

"relating to or consisting of molecules," by 1815, from molecule + -ar or else from French moléculaire or Modern Latin molecularis. Molecular biology is attested by 1950.