Etymology
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missus (n.)

also missis, a colloquial contraction of mistress; as the oral form of Mrs., from 1790; the missus "the wife" is attested by 1833.

updated on February 02, 2019

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Definitions of missus from WordNet

missus (n.)
informal term of address for someone's wife;
Synonyms: missis
Etymologies are not definitions. From wordnet.princeton.edu, not affiliated with etymonline.