1530s, "to have doubts (of the reality of), to suspect, to regard (the truth or reality of) with suspicion," from mis- (1) "badly, wrongly" + doubt (v.). Meaning "to fear or suspect (the existence of something evil) is from 1560s. Intransitive sense of "entertain doubt" is from 1630s. Related: Misdoubted; misdoubting. As a noun, "irresolution," 1590s.