from Spanish, from Nahuatl (Aztecan) mexihco.
The etymology of this is opaque. Because of the difference in vowel length, it cannot be derived from ME-TL 'maguey.' The sequence XIH also differs in vowel length from XIC-TLI 'navel,' which has been proposed as a component element. The final element is locative -C(O). [Kartunnen]